Jaime Mata, MS, PhD

Professor of Radiology and Medical Imaging
Assistant Director of the Center for In-vivo HPG MRI

PhD, Biomedical Engineering, University of Virginia, Charlottesville, VA, 2006
MS, Biomedical Engineering, University of Virginia, Charlottesville, VA, 2001
BS, Applied Physics, University of Lisbon (FCUL); Lisbon, Portugal, 1997

University of Virginia
Department of Radiology and Medical Imaging
480 Ray C Hunt Drive
Snyder Building
Charlottesville, VA 22903

434-243-6498
[email protected]

Research Interests

Research focused on early detection and characterization of disease using novel techniques, as well as minimally invasive treatments for cancer:

Non-invasive Cytoreductive Surgical Treatment of Lung Cancer and of Pleural Mesothelioma.
Regional Quantification of Lung Function in Cystic Fibrosis and Lung Cancer using Xe129 MRI.
Non-invasive Targeted Delivery and In-vivo Evaluation of Brain Therapy using MR guided Focused Ultrasound.
Brain infusion using Convection Enhanced Delivery (CED).

Research Labs

Honors

2011 Research Scientist Award – American Society of Neuroradiology (ASNR)

Books Published

Jaime Mata. Hyperpolarized Gas MRI to Evaluate Emphysema – A new biomarker with high sensitivity. Verlag. April 2008. ISBN: 978-3-8364-6836-7.

U.S. and International Patents

U.S. Patent No US 2007/0197903 A1, International Application No PCT/US2005/0080058. Title: System and Method for Improved Detection and Assessment of Changes in Lung-Tissue Structure.

U.S. Patent Application No. 12/771, 767, filled April 30, 2010. Title: “Single Breath-hold System and Method for Detection and Assessment of Multi-Organ Physiologic, Morphologic and Structural Changes”. Primary inventor.

Current and Past Projects

Current:

1RO1CA172595-01 (Mata J.) – Scored at top 8%.
Source: National Institutes of Health (NIH) – National Cancer Institute (NCI);
“Regional Quantification of Lung Function in Cystic Fibrosis using Xe129 MRI”
Role: PI

ASNR-NERF (Mata J.)
Source: American Society of NeuroRadiology-Neuroradiology Education & Research Foundation
“Non-invasive Targeted Delivery and In-vivo Evaluation of Brain Therapy using MR guided Focused Ultrasound.”
Role: PI

1RO1 HL109618-01 (Mugler J. & Altes T.)
Source: NIH/NHLBI
“Simultaneous Xe-129 MRI of regional Lung Ventilation and gas uptake in COPD.”
Role: Co-Investigator

VX10-770-107 (Altes, T.)
Source: Vertex Pharmaceuticals, Inc.
“A Phase II, Single-Blind, Placebo-Controlled Crossover Study to Evaluate the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects with Cystic Fibrosis, the G551D
Mutation and FEV1 ≥40% Predicted.”
Role: Co-Investigator

UVA-2008-MR-01-01 (Mugler J.)
Source: Siemens Medical Solutions
“Techniques and Infrastructure for Hyperpolarized-Gas MRI.”
Role: Co-Investigator

XCOVERY (Mata J.)
Source: Xcovery, LLC
“Testing the efficacy of X-82 in an animal model of lung radiation injury.” Role: PI

Completed:

PR10580019 (Mata J.)
Source: Department of Defense/Army
“Non-invasive Cytoreductive Surgical Treatment of Lung Mesothelioma.”
Role: PI

TwinStar (Mata J.)
Source: TwinStar LLC
“Preliminary Studies of Infusion using TwinStar Catheter in Porcine.”
Role: PI

CCSG (Mata J.)
Source: University of Virginia Cancer Center
“Orthotopic small animal model of lung cancer to study feasibility of a novel functional MRI technique for early predictive information regarding the efficacy of lung cancer treatments.”
Role: PI

1R21 HL089525-01 (Miller)
Source:NIH/NHLBI
“Very-short-time Diffusion MRI of Hyperpolarized Gases.”
Role: Co-Investigator

R01 EB003202 (Ruppert/Hagspiel)
Source: NIH-NIBIB
“Lung Pathology Detection Using Hyperpolarized 129Xe.”
Role: Co-Investigator

SOM R&D (Mata J.)
Source: UVa School of Medicine Research and Development Award
“Early detection and evaluation of treatment efficacy in an animal model of lung cancer using novel MRI contrast agents.”
Role: PI

CCSG (Read, P.)
Source: University of Virginia Cancer Center
“Maximizing the efficacy of lung radiosurgery using Amifostine in a rabbit model system.”
Role: Co-Investigator

RSNA Seed Grant (Miller, G.)
Source: Radiological Society of North America
“Evaluation of Three Methods for Regional Mapping of Intrapulmonary Oxygen Partial Pressures with Helium-3 MRI.”
Role: Co-Investigator

IN2002-01 (Brookeman/Mugler)
Source: Commonwealth Technology Research Fund – Commonwealth of Virginia
“Center for In-Vivo Hyperpolarized Gas MR Imaging.”
Role: Co-Investigator

Publications

1- Mata J., Altes T., Mugler J., Brookeman J.. MRI of the Human Lungs with Hyperpolarized Helium-3: Preliminary Considerations of Appropriate Dose. Magma2000, 11(1):260.

Ruppert K, Mata J, Brookeman J, Hagspiel K, Mugler III J. Exploring Lung Function with Hyperpolarized ¹²⁹Xe Nuclear Magnetic Resonance. Magn. Reson. Med. 2004, 51(4), 676-687.

2- Altes T, Mata J, de Lange E, Brookeman J, Mugler III J. Assessment of lung development using hyperpolarized helium-3 diffusion MR imaging. J Magn Reson Imaging 2006;24(6):1277-1283.

3- Mata J, Altes T, Cai J, Ruppert K, Mitzner W, Hagspiel K, Patel B, Salerno M, Brookeman J, de Lange E, Tobias W, Wang H, Cates G, Mugler III J. Evaluation of Emphysema Severity and Progression in a Rabbit Model: A Comparison of Hyperpolarized He-3 and Xe-129 Diffusion MRI with Lung Morphometry. J Appl Physiol., 2007 Mar; 102(3), 1273-80.

4- Ruppert K., Mata J., Wang H., Tobias W., Cates G., Brookeman J., Hagspiel K. D., Mugler, J. XTC MRI: sensitivity improvement through parameter optimization. Magn Reson Med 2007; 57(6): 1099-109.

5- Mata J, Altes T, Knake J, Mugler J, Brookeman J, de Lange E. Hyperpolarized ³He MR imaging of the lung: Effect of subject immobilization on the occurrence of ventilation defects. Acad. Radiol. 2008; 15:260-264.

6- Miller G, Carl M, Mata J, Cates G, Mugler J. Simulations of short-time diffusivity in lung airspaces and implications for S/V measurements using hyperpolarized-gas MRI. IEEE Trans. Med. Imag., vol. 26, no. 11, Nov. 2007, pp. 1456-1463.

7- Mata J, Sheng K, Hagspiel K, et al. Assessment of Amifostine in a Rabbit Model of Radiation Lung Injury: Preliminary Results. International Journal of Radiation Oncology*Biology*Physics 2008;72:S699.1.

8- Greaves I, Hsia C, Hyde D, Ochs M, Weibel E, Bates J, Rossiter H, Breen E, Parameswaran H, Majumdar A, Hamakawa H, Suki B, Fehrenbach H, Mata J.Commentaries on Viewpoint: Use of mean airspace chord length to assess emphysema. J Appl Physiol. 2008 Dec;105(6):1982-1985.

9- Cai J, Mata J, Orton M, Hagspiel KD, Mugler III JP, Larner J, Sheng K, Read P. A rabbit irradiation platform for outcome assessment of lung stereotactic radiosurgery.Int J Rad Onc Biol Phys. 2009 Apr; 73(5):1588–95.

10- Mata J, Altes T.A, Ruppert K, Hagspiel K, Miller G.W, Brookeman J.R, Mugler J.P.Assessment of In-vitro Lung Structure using Hyperpolarized Helium-3 Diffusion MRI: Comparison with In-vivo Measurements and Repeatability. Magn Reson Imaging.2009, 27:845-851.

11- Mata J, Bozlar U, Berr S, Mugler III J, Miller G, Hagspiel K. High-resolution MRA and first-pass perfusion imaging in a rabbit model of pulmonary embolism at 7.0 Tesla: preliminary results. Magn Reson Imaging. 2010 Jan;28(1):139-45.

12- Mugler JP 3rd, Altes TA, Ruset IC, Dregely IM, Mata JF, Miller GW, Ketel S, Ketel J, Hersman FW, Ruppert K. Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129.PNAS. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21707-12. PMCID: PMC3003026

13- Dregely I, Mugler JP III, Ruset IC, Altes TA, Mata JF, Miller GW, Ketel J. Ketel S, Distelbrink J, Hersman FW. Ruppert K. Hyperpolarized xenon-129 gas-exchange imaging of lung microstructure: First case studies in subjects with obstructive lung disease. J Magn Reson Imaging 2011; 33(5):1052-1062. PMCID: PMC3081140

14- Mata J, Altes T, Truwit J, de Lange E, Shim Y, Vinayak A, Sylvester P, Brookeman J, Mugler III J. Characterization and detection of physiologic lung changes before and after placement of bronchial valves using hyperpolarized helium-3 MR imaging: preliminary study. Academic Radiology 18, 11950 (2011). PMCID: PMC3152599